Is Hair Loss Genetic? Understanding Androgenetic Alopecia

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Written By harley haircentre
A medical infographic showing the hereditary path of hair loss genes and how the 5-alpha reductase enzyme affects genetically predisposed hair follicles.

While genetic predisposition is the primary cause of baldness, the presence of the gene doesn't always guarantee hair loss.

What is Genetic Susceptibility to Hair Loss?

Genetic predisposition to hair loss can be understood as a hereditary susceptibility of hair follicle to male hormone (Androgen)... Androgenetic alopecia only affects individuals who inherited the gene from either parent.

The Role of the 5-Alpha Reductase Enzyme

  • How the Baldness Gene Works

The gene responsible for androgenic alopecia codes for an important enzyme 5-alpha reductase that converts Testosterone to its active form Dihydrotestosterone (DHT)...

  • DHT Sensitivity and Hair Follicle Miniaturization

Androgen receptor activation on the hair follicles causes the hair to become smaller and thinner. This is especially true for individuals whose hair follicles are genetically predisposed to become oversensitive to DHT.

  • Important Note on Genetic Expression

However, it is important to note that not everyone who carries the gene susceptible for androgenic alopecia will develop hair loss.

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Hormones and Hair Loss: Why DHT is the Main Culprit.